Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids

• Main Authors: Polizzi, Arnaud, Fouché, Edwin, Ducheix, Simon, Lasserre, Frédéric, Marmugi, Alice P., Mselli-Lakhal, Laila, Loiseau, Nicolas, Wahli, Walter, Guillou, Hervé, Montagner, Alexandra
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: nuclear receptors; PPARα
• Online Access: https://hdl.handle.net/10356/84062; http://hdl.handle.net/10220/41598
• Institution: Nanyang Technological University

The liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the li...