Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

• Main Authors: Rando, Gianpaolo, Tan, Chek Kun, Khaled, Nourhène, Montagner, Alexandra, Leuenberger, Nicolas, Bertrand-Michel, Justine, Paramalingam, Eeswari, Guillou, Hervé, Wahli, Walter
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: PPARα; lipid catabolism
• Online Access: https://hdl.handle.net/10356/82215; http://hdl.handle.net/10220/41171
• Institution: Nanyang Technological University

In mammals, hepatic lipid catabolism is essential for the newborns to efficiently use milk fat as an energy source. However, it is unclear how this critical trait is acquired and regulated. We demonstrate that under the control of PPARα, the genes required for lipid catabolism are transcribed before...