Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

• المؤلفون الرئيسيون: Rando, Gianpaolo, Tan, Chek Kun, Khaled, Nourhène, Montagner, Alexandra, Leuenberger, Nicolas, Bertrand-Michel, Justine, Paramalingam, Eeswari, Guillou, Hervé, Wahli, Walter
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: PPARα; lipid catabolism
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82215; http://hdl.handle.net/10220/41171
• المؤسسة: Nanyang Technological University

In mammals, hepatic lipid catabolism is essential for the newborns to efficiently use milk fat as an energy source. However, it is unclear how this critical trait is acquired and regulated. We demonstrate that under the control of PPARα, the genes required for lipid catabolism are transcribed before...