Substrate-induced structural alterations of Mycobacterial mycothione reductase and critical residues involved

• Main Authors: Kumar, Arvind, Subramanian Manimekalai, Malathy Sony, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Mycothiol; Oxidative Stress
• Online Access: https://hdl.handle.net/10356/145102
• Institution: Nanyang Technological University

Redox homeostasis is a prerequisite for survival of the pathogen Mycobacterium tuberculosis (Mtb) which employs the low molecular weight thiol mycothiol (MSH). The Mycobacterial NADPH-dependent mycothione reductase (MtMtr), composed of an NADPH-, FAD-, and a dimerization-domain connected by linkers,...