Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs

• Main Authors: Maity, Arijit, Winnerdy, Fernaldo Richtia, Chang, Weili Denyse, Chen, Gang, Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; DNA; Guanine
• Online Access: https://hdl.handle.net/10356/145156
• Institution: Nanyang Technological University

G-rich DNA sequences with tracts of three or more continuous guanines (G≥3) are known to have high propensity to adopt stable G-quadruplex (G4) structures. Bioinformatic analyses suggest high prevalence of G-rich sequences with short G-tracts (G≤2) in the human genome. However, due to limited struct...