METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing

• Main Authors: Goh, Yeek Teck, Koh, Casslynn W. Q., Sim, Donald Yuhui, Roca, Xavier, Goh, W. S. Sho
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; METTL4; Methylation
• Online Access: https://hdl.handle.net/10356/145157
• Institution: Nanyang Technological University

N6-methylation of 2′-O-methyladenosine (Am) in RNA occurs in eukaryotic cells to generate N6,2′-O-dimethyladenosine (m6Am). Identification of the methyltransferase responsible for m6Am catalysis has accelerated studies on the function of m6Am in RNA processing. While m6Am is generally found in the f...