Whole-cell phenotypic screening of Medicines for Malaria Venture Pathogen Box identifies specific inhibitors of Plasmodium falciparum late-stage development and egress

• Main Authors: Patra, Alok Tanala, Hingamire, Tejashri, Belekar, Meenakshi A., Xiong, Aoli, Subramanian, Gowtham, Bozdech, Zbynek, Preiser, Peter, Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Phenotypic Screening; Plasmodium Falciparum
• Online Access: https://hdl.handle.net/10356/145209
• Institution: Nanyang Technological University

We report a systematic, cellular phenotype-based antimalarial screening of the Medicines for Malaria Venture Pathogen Box collection, which facilitated the identification of specific blockers of late-stage intraerythrocytic development of Plasmodium falciparum First, from standard growth inhibition...