Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa

• Main Authors: Simam, Joan, Rono, Martin, Ngoi, Joyce, Nyonda, Mary, Mok, Sachel, Marsh, Kevin, Bozdech, Zbynek, Mackinnon, Margaret
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Plasmodium Falciparum; Copy Number Variation
• Online Access: https://hdl.handle.net/10356/84292; http://hdl.handle.net/10220/45112
• Institution: Nanyang Technological University

Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed their important role in parasite fitness phenotypes such as r...