Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression

• Main Authors: Park, Jung Eun, Tse, Shun Wilford, Xue, Guo, Assisi, Christina, Maqueda, Aida Serra, Ramon, Gallart Palau Xavier, Low, Jee Keem, Kon, Oi Lian, Tay, Chor Yong, Tam, James P., Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Hypoxia; pSILAC
• Online Access: https://hdl.handle.net/10356/145346
• Institution: Nanyang Technological University

Hypoxia is an environmental cue that is associated with multiple tumorigenic processes such as immunosuppression, angiogenesis, cancer invasion, metastasis, drug resistance, and poor clinical outcomes. When facing hypoxic stress, cells initiate several adaptive responses such as cell cycle arrest to...