Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing

• Main Authors: Xing, Qiao Rui, El Farran, C. A., Gautam, P., Chuah, Y. S., Warrier, T., Toh, C. X. D., Kang, N. Y., Sugii, S., Chang, Y. T., Xu, J., Collins, J. J., Daley, G. Q., Li, H., Zhang, Li-Feng, Loh, Y. H.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Chromosomes; Machinery
• Online Access: https://hdl.handle.net/10356/145388
• Institution: Nanyang Technological University

Cellular reprogramming suffers from low efficiency especially for the human cells. To deconstruct the heterogeneity and unravel the mechanisms for successful reprogramming, we adopted single-cell RNA sequencing (scRNA-Seq) and single-cell assay for transposase-accessible chromatin (scATAC-Seq) to pr...