Predictive testing for tumor predisposition syndromes in pediatric relatives : an Asian experience

• Main Authors: Chiang, Jianbang, Yuen, Jeanette, Shaw, Tarryn, Goh, Hui Xuan, Li, Shao-Tzu, Courtney, Eliza, Ngeow, Joanne
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Predictive Testing; Cascade
• Online Access: https://hdl.handle.net/10356/145546
• Institution: Nanyang Technological University

Approximately 10% of pediatric cancer patients possess germline pathogenic/likely pathogenic variants (PV/LPV) in known tumor predisposition genes. Predictive testing is the optimal approach to identify asymptomatic at-risk relatives to guide gene-directed surveillance for early cancer detection and...