The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy

The tumor microenvironment (TME) consists of extracellular matrix proteins, immune cells, vascular cells, lymphatics and fibroblasts. Under normal physiological conditions, tissue homeostasis protects against tumor development. However, under pathological conditions, interplay between the tumor and...

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Main Authors: Wo, Yu Jun, Gan, Adelia Shin Ping, Lim, Xinru, Tay, Isabel Shu Ying, Lim, Sherlly, Lim, Jeffrey Chun Tatt, Yeong, Joe Poh Sheng
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/145605
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1456052023-03-05T16:48:00Z The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy Wo, Yu Jun Gan, Adelia Shin Ping Lim, Xinru Tay, Isabel Shu Ying Lim, Sherlly Lim, Jeffrey Chun Tatt Yeong, Joe Poh Sheng Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine CD38 CD157 The tumor microenvironment (TME) consists of extracellular matrix proteins, immune cells, vascular cells, lymphatics and fibroblasts. Under normal physiological conditions, tissue homeostasis protects against tumor development. However, under pathological conditions, interplay between the tumor and its microenvironment can promote tumor initiation, growth and metastasis. Immune cells within the TME have an important role in the formation, growth and metastasis of tumors, and in the responsiveness of these tumors to immunotherapy. Recent breakthroughs in the field of cancer immunotherapy have further highlighted the potential of targeting TME elements, including these immune cells, to improve the efficacy of cancer prognostics and immunotherapy. CD38 and CD157 are glycoproteins that contribute to the tumorigenic properties of the TME. For example, in the hypoxic TME, the enzymatic functions of CD38 result in an immunosuppressive environment. This leads to increased immune resistance in tumor cells and allows faster growth and proliferation rates. CD157 may also aid the production of an immunosuppressive TME, and confers increased malignancy to tumor cells through the promotion of tumor invasion and metastasis. An improved understanding of CD38 and CD157 in the TME, and how these glycoproteins affect cancer progression, will be useful to develop both cancer prognosis and treatment methods. This review aims to discuss the roles of CD38 and CD157 in the TME and cancer immunotherapy of a range of solid tumor types. Published version 2020-12-30T02:42:26Z 2020-12-30T02:42:26Z 2019 Journal Article Wo, Y. J., Gan, A. S. P., Lim, X., Tay, I. S. Y., Lim, S., Lim, J. C. T., & Yeong, J. P. S. (2019). The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy. Cells, 9(1), 26-. doi:10.3390/cells9010026 2073-4409 https://hdl.handle.net/10356/145605 10.3390/cells9010026 31861847 1 9 en Cells © 2019 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
CD38
CD157
spellingShingle Science::Medicine
CD38
CD157
Wo, Yu Jun
Gan, Adelia Shin Ping
Lim, Xinru
Tay, Isabel Shu Ying
Lim, Sherlly
Lim, Jeffrey Chun Tatt
Yeong, Joe Poh Sheng
The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy
description The tumor microenvironment (TME) consists of extracellular matrix proteins, immune cells, vascular cells, lymphatics and fibroblasts. Under normal physiological conditions, tissue homeostasis protects against tumor development. However, under pathological conditions, interplay between the tumor and its microenvironment can promote tumor initiation, growth and metastasis. Immune cells within the TME have an important role in the formation, growth and metastasis of tumors, and in the responsiveness of these tumors to immunotherapy. Recent breakthroughs in the field of cancer immunotherapy have further highlighted the potential of targeting TME elements, including these immune cells, to improve the efficacy of cancer prognostics and immunotherapy. CD38 and CD157 are glycoproteins that contribute to the tumorigenic properties of the TME. For example, in the hypoxic TME, the enzymatic functions of CD38 result in an immunosuppressive environment. This leads to increased immune resistance in tumor cells and allows faster growth and proliferation rates. CD157 may also aid the production of an immunosuppressive TME, and confers increased malignancy to tumor cells through the promotion of tumor invasion and metastasis. An improved understanding of CD38 and CD157 in the TME, and how these glycoproteins affect cancer progression, will be useful to develop both cancer prognosis and treatment methods. This review aims to discuss the roles of CD38 and CD157 in the TME and cancer immunotherapy of a range of solid tumor types.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Wo, Yu Jun
Gan, Adelia Shin Ping
Lim, Xinru
Tay, Isabel Shu Ying
Lim, Sherlly
Lim, Jeffrey Chun Tatt
Yeong, Joe Poh Sheng
format Article
author Wo, Yu Jun
Gan, Adelia Shin Ping
Lim, Xinru
Tay, Isabel Shu Ying
Lim, Sherlly
Lim, Jeffrey Chun Tatt
Yeong, Joe Poh Sheng
author_sort Wo, Yu Jun
title The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy
title_short The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy
title_full The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy
title_fullStr The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy
title_full_unstemmed The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy
title_sort roles of cd38 and cd157 in the solid tumor microenvironment and cancer immunotherapy
publishDate 2020
url https://hdl.handle.net/10356/145605
_version_ 1759852977682644992