The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy

• Main Authors: Wo, Yu Jun, Gan, Adelia Shin Ping, Lim, Xinru, Tay, Isabel Shu Ying, Lim, Sherlly, Lim, Jeffrey Chun Tatt, Yeong, Joe Poh Sheng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; CD38; CD157
• Online Access: https://hdl.handle.net/10356/145605
• Institution: Nanyang Technological University

The tumor microenvironment (TME) consists of extracellular matrix proteins, immune cells, vascular cells, lymphatics and fibroblasts. Under normal physiological conditions, tissue homeostasis protects against tumor development. However, under pathological conditions, interplay between the tumor and...