CD4+ T cells mediate the development of liver fibrosis in high fat diet-induced NAFLD in humanized mice

• المؤلفون الرئيسيون: Her, Zhisheng, Tan, Joel Heng Loong, Lim, Yee-Siang, Tan, Sue Yee, Chan, Xue Ying, Tan, Wilson Wei Sheng, Liu, Min, Yong, Kylie Su Mei, Lai, Fritz, Ceccarello, Erica, Zheng, Zhiqiang, Fan, Yong, Chang, Kenneth Tou En, Sun, Lei, Chang, Shih Chieh, Chin, Chih-Liang, Lee, Guan Huei, Dan, Yock Young, Chan, Yun-Shen, Lim, Seng Gee, Chan, Jerry Kok Yen, Chandy, Kanianthara George, Chen, Qingfeng
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Humanized Mouse Model; NAFLD
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/145632

Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) involves chronic inflammation, and CD4+ T cell infiltration of...