CD4+ T cells mediate the development of liver fibrosis in high fat diet-induced NAFLD in humanized mice

• Main Authors: Her, Zhisheng, Tan, Joel Heng Loong, Lim, Yee-Siang, Tan, Sue Yee, Chan, Xue Ying, Tan, Wilson Wei Sheng, Liu, Min, Yong, Kylie Su Mei, Lai, Fritz, Ceccarello, Erica, Zheng, Zhiqiang, Fan, Yong, Chang, Kenneth Tou En, Sun, Lei, Chang, Shih Chieh, Chin, Chih-Liang, Lee, Guan Huei, Dan, Yock Young, Chan, Yun-Shen, Lim, Seng Gee, Chan, Jerry Kok Yen, Chandy, Kanianthara George, Chen, Qingfeng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Humanized Mouse Model; NAFLD
• Online Access: https://hdl.handle.net/10356/145632
• Institution: Nanyang Technological University

Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) involves chronic inflammation, and CD4+ T cell infiltration of...