Sex steroids induce membrane stress responses and virulence properties in Pseudomonas aeruginosa

• Main Authors: Vidaillac, Celine, Yong, Valerie Fei Lee, Aschtgen, Marie-Stephanie, Qu, Jing, Yang, Shuowei, Xu, Guangfu, Seng, Zi Jing, Brown, Alexandra C., Ali, Md Khadem, Jaggi, Tavleen K., Sankaran, Jagadish, Foo, Yong Hwee, Righetti, Francesco, Nedumaran, Anu Maashaa, Mac Aogáin, Micheál, Roizman, Dan, Richard, Jean-Alexandre, Rogers, Thomas R., Toyofuku, Masanori, Luo, Dahai, Loh, Edmund, Wohland, Thorsten, Czarny, Bertrand, Horvat, Jay C., Hansbro, Philip M., Yang, Liang, Li, Liang, Normark, Staffan, Henriques-Normark, Birgitta, Chotirmall, Sanjay Haresh
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Hormones; Steroids
• Online Access: https://hdl.handle.net/10356/145844
• Institution: Nanyang Technological University

Estrogen, a major female sex steroid hormone, has been shown to promote the selection of mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases, including cystic fibrosis. This results in long-term persistence, poorer clinical outcomes, and limited therapeutic opt...