Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle

• المؤلفون الرئيسيون: Mehta, Sunali, McKinney, Cushla, Algie, Michael, Verma, Chandra Shekhar, Kannan, Srinivasaraghavan, Harfoot, Rhodri, Bartolec, Tara K., Bhatia, Puja, Fisher, Alistair J., Gould, Maree L., Parker, Kim, Cesare, Anthony J., Cunliffe, Heather E., Cohen, Scott B., Kleffmann, Torsten, Braithwaite, Antony W., Woolley, Adele G.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Biological sciences; YB-1; Cell Cycle
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/145956

Elevated levels of nuclear Y-box binding protein 1 (YB-1) are linked to poor prognosis in cancer. It has been proposed that entry into the nucleus requires specific proteasomal cleavage. However, evidence for cleavage is contradictory and high YB-1 levels are prognostic regardless of cellular locati...