Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle

• Main Authors: Mehta, Sunali, McKinney, Cushla, Algie, Michael, Verma, Chandra Shekhar, Kannan, Srinivasaraghavan, Harfoot, Rhodri, Bartolec, Tara K., Bhatia, Puja, Fisher, Alistair J., Gould, Maree L., Parker, Kim, Cesare, Anthony J., Cunliffe, Heather E., Cohen, Scott B., Kleffmann, Torsten, Braithwaite, Antony W., Woolley, Adele G.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; YB-1; Cell Cycle
• Online Access: https://hdl.handle.net/10356/145956
• Institution: Nanyang Technological University

Elevated levels of nuclear Y-box binding protein 1 (YB-1) are linked to poor prognosis in cancer. It has been proposed that entry into the nucleus requires specific proteasomal cleavage. However, evidence for cleavage is contradictory and high YB-1 levels are prognostic regardless of cellular locati...