Defining the structural basis for human leukocyte antigen reactivity in clinical transplantation

• Main Authors: Gu, Yue, Koh, Robynne W. K., Lai, May Ling, Pochinco, Denise, Teo, Rachel Z. C., Chan, Marieta, Murali, Tanusya M., Liew, Chong Wai, Wong, Yee Hwa, Gascoigne, Nicholas R. J., Wood, Kathryn J., Lescar, Julien, Nickerson, Peter, MacAry, Paul A., Vathsala, Anantharaman
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Immunology; Medical Research
• Online Access: https://hdl.handle.net/10356/146045
• Institution: Nanyang Technological University

The current state-of-the-art technology employed to assess anti-human leukocyte antigen antibodies (Anti-HLA Ab) for donor-recipient matching and patient risk stratification in renal transplantation is the single antigen bead (SAB) assay. However, there are limitations to the SAB assay as it is not...