A non-viral genome editing platform for site-specific insertion of large transgenes

• Main Authors: Chaudhari, Namrata, Rickard, Amanda M., Roy, Suki, Dröge, Peter, Makhija, Harshyaa
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Genome Engineering; Gene Therapy
• Online Access: https://hdl.handle.net/10356/146047
• Institution: Nanyang Technological University

Background: The precise, functional and safe insertion of large DNA payloads into host genomes offers versatility in downstream genetic engineering-associated applications, spanning cell and gene therapies, therapeutic protein production, high-throughput cell-based drug screening and reporter cell l...