Weighted persistent homology for osmolyte molecular aggregation and hydrogen-bonding network analysis

• Main Authors: Anand, D. Vijay, Meng, Zhenyu, Xia, Kelin, Mu, Yuguang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Biochemistry; Structural Biology
• Online Access: https://hdl.handle.net/10356/146107
• Institution: Nanyang Technological University

It has long been observed that trimethylamine N-oxide (TMAO) and urea demonstrate dramatically different properties in a protein folding process. Even with the enormous theoretical and experimental research work on these two osmolytes, various aspects of their underlying mechanisms still remain larg...