Interaction of nanoparticles with human skin

• Main Author: Goh, Bernice Huan Rong
• Other Authors: Ng Kee Woei
• Format: Thesis-Master by Research
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Engineering::Materials
• Online Access: https://hdl.handle.net/10356/146115
• Institution: Nanyang Technological University

Nanoparticles (NPs) have been incorporated as active ingredients in a diverse range of consumer products such as oral hygiene products and cosmetics, increasing the possible interaction between NPs and the human body. Due to their UV filtering ability, titanium dioxide (TiO2) and zinc oxide (ZnO) NPs have been widely utilized in sunscreens and whitening creams. The widespread usage of these NPs has led to increase concerns on the possible penetration of these NPs into skin and potential adverse outcomes to human skin due to prolong exposure to nano-enabled consumer skin products. In particular, the influence of NPs on wound healing has not been documented. In a wound scenario, application of nano-enabled skin products could lead to NPs interacting with the living skin cells and tissue. Thus, this study aims to evaluate the interaction of TiO2 and ZnO NPs with human epidermal keratinocytes, specifically in a wound setting and the biological outcomes resulted from this interaction.