Lgr5 marks adult progenitor cells contributing to skeletal muscle regeneration and sarcoma formation

• Main Authors: Leung, Carly, Katzrin Bte Ahmad Murad, Tan, Adelyn Liang Thing, Yada, Swathi, Sagiraju, Sowmya, Bode, Peter Karl, Barker, Nick
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Lgr5; Muscle Regeneration
• Online Access: https://hdl.handle.net/10356/146148
• Institution: Nanyang Technological University

Regeneration of adult skeletal muscle is driven largely by resident satellite cells, a stem cell population increasingly considered to display a high degree of molecular heterogeneity. In this study, we find that Lgr5, a receptor for Rspo and a potent mediator of Wnt/β-catenin signaling, marks a sub...