A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis

A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis

Lgr5+ crypt base columnar cells, the operational intestinal stem cells (ISCs), are thought to be dispensable for small intestinal (SI) homeostasis. Using a Lgr5-2A-DTR (diphtheria toxin receptor) model, which ablates Lgr5+ cells with near-complete efficiency and retains endogenous levels of Lgr5 exp...

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Bibliographic Details
Main Authors: Tan, Si Hui, Phuah, Phyllis, Tan, Liang Thing, Yada, Swathi, Goh, Jasmine, Tomaz, Lucian B., Chua, Magdalene, Wong, Esther, Lee, Bernett, Barker, Nick
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Lgr5
DTR
Online Access:https://hdl.handle.net/10356/146864
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/146864

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