A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis

• Main Authors: Tan, Si Hui, Phuah, Phyllis, Tan, Liang Thing, Yada, Swathi, Goh, Jasmine, Tomaz, Lucian B., Chua, Magdalene, Wong, Esther, Lee, Bernett, Barker, Nick
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Lgr5; DTR
• Online Access: https://hdl.handle.net/10356/146864
• Institution: Nanyang Technological University

Lgr5+ crypt base columnar cells, the operational intestinal stem cells (ISCs), are thought to be dispensable for small intestinal (SI) homeostasis. Using a Lgr5-2A-DTR (diphtheria toxin receptor) model, which ablates Lgr5+ cells with near-complete efficiency and retains endogenous levels of Lgr5 exp...