Size-transformable nanostructures : from design to biomedical applications

The size of nanostructures (NSs) strongly affects their chemical and physical properties and further impacts their actions in biological systems. Both small and large NSs possess respective advantages for disease theranostics, and this therefore presents a paradox when choosing NSs with suitable siz...

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Main Authors: Zhang, Xiaodong, Chen, Xiaokai, Song, Jun, Zhang, Junmin, Ren, Xiangzhong, Zhao, Yanli
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/146303
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1463032023-02-28T19:21:37Z Size-transformable nanostructures : from design to biomedical applications Zhang, Xiaodong Chen, Xiaokai Song, Jun Zhang, Junmin Ren, Xiangzhong Zhao, Yanli School of Physical and Mathematical Sciences Science::Medicine Bacterial Infection Cancer Treatment The size of nanostructures (NSs) strongly affects their chemical and physical properties and further impacts their actions in biological systems. Both small and large NSs possess respective advantages for disease theranostics, and this therefore presents a paradox when choosing NSs with suitable sizes. To overcome this challenge, size-transformable NSs have emerged as a powerful tool, as they can be manipulated to possess the merits of both types of NSs. Herein, various strategies to construct size-transformable NSs are summarized, and the recent research progress regarding their biomedical applications, particularly within the fields of cancer and bacterial theranostics, is highlighted. This review will inspire researchers to further develop various methods that can be used to construct size-transformable NSs for use in novel applications within different fields. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) National Research Foundation (NRF) Accepted version This research is supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A1883c0005), the Singapore Academic Research Fund (RT12/19), the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03), the National Natural Science Foundation of China (21671136), the Principal Foundation of Shenzhen University (8570700000307), and the Shenzhen Science and Technology Foundation (KQJSCX20180328100401788). 2021-02-08T08:04:17Z 2021-02-08T08:04:17Z 2020 Journal Article Zhang, X., Chen, X., Song, J., Zhang, J., Ren, X., & Zhao, Y. (2020). Size-transformable nanostructures : from design to biomedical applications. Advanced Materials, 32(48), 2003752-. doi:10.1002/adma.202003752 0935-9648 https://hdl.handle.net/10356/146303 10.1002/adma.202003752 48 32 2003752 en Advanced Materials This is the accepted version of the following article: Zhang, X., Chen, X., Song, J., Zhang, J., Ren, X., & Zhao, Y. (2020). Size-transformable nanostructures : from design to biomedical applications. Advanced Materials, 32(48), 2003752-. doi:10.1002/adma.202003752, which has been published in final form at https://doi.org/10.1002/adma.202003752. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html]. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Bacterial Infection
Cancer Treatment
spellingShingle Science::Medicine
Bacterial Infection
Cancer Treatment
Zhang, Xiaodong
Chen, Xiaokai
Song, Jun
Zhang, Junmin
Ren, Xiangzhong
Zhao, Yanli
Size-transformable nanostructures : from design to biomedical applications
description The size of nanostructures (NSs) strongly affects their chemical and physical properties and further impacts their actions in biological systems. Both small and large NSs possess respective advantages for disease theranostics, and this therefore presents a paradox when choosing NSs with suitable sizes. To overcome this challenge, size-transformable NSs have emerged as a powerful tool, as they can be manipulated to possess the merits of both types of NSs. Herein, various strategies to construct size-transformable NSs are summarized, and the recent research progress regarding their biomedical applications, particularly within the fields of cancer and bacterial theranostics, is highlighted. This review will inspire researchers to further develop various methods that can be used to construct size-transformable NSs for use in novel applications within different fields.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Zhang, Xiaodong
Chen, Xiaokai
Song, Jun
Zhang, Junmin
Ren, Xiangzhong
Zhao, Yanli
format Article
author Zhang, Xiaodong
Chen, Xiaokai
Song, Jun
Zhang, Junmin
Ren, Xiangzhong
Zhao, Yanli
author_sort Zhang, Xiaodong
title Size-transformable nanostructures : from design to biomedical applications
title_short Size-transformable nanostructures : from design to biomedical applications
title_full Size-transformable nanostructures : from design to biomedical applications
title_fullStr Size-transformable nanostructures : from design to biomedical applications
title_full_unstemmed Size-transformable nanostructures : from design to biomedical applications
title_sort size-transformable nanostructures : from design to biomedical applications
publishDate 2021
url https://hdl.handle.net/10356/146303
_version_ 1759856770917859328