Dual gate-controlled therapeutics for overcoming bacterium-induced drug resistance and potentiating cancer immunotherapy

• Main Authors: Zhang, Xiaodong, Chen, Xiaokai, Guo, Yuxin, Gao, Ge, Wang, Dongdong, Wu, Yinglong, Liu, Jiawei, Liang, Gaolin, Zhao, Yanli, Wu, Fu-Gen
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Bacterial Infection; Cancer Therapy
• Online Access: https://hdl.handle.net/10356/162861
• Institution: Nanyang Technological University

The presence of bacteria in the tumor can cause cancer resistance to chemotherapeutics. To fight against bacterium-induced drug resistance, herein we design self-traceable nanoreservoirs that are simultaneously loaded with gemcitabine (an anticancer drug) and ciprofloxacin (an antibiotic) and are de...