Metal−organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy

• Main Authors: Wang, Dongdong, Wu, Huihui, Yang, Guangbao, Qian, Cheng, Gu, Long, Wang, Hou, Zhou, Weiqiang, Liu, Jiawei, Wu, Yinglong, Zhang, Xiaodong, Guo, Zhen, Chen, Hongzhong, Jana, Deblin, Zhao, Yanli
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Glutathione; Metal-organic Frameworks
• Online Access: https://hdl.handle.net/10356/146323
• Institution: Nanyang Technological University

Intracellular antioxidants such as glutathione (GSH) play a critical role in protecting malignant tumor cells from apoptosis induced by reactive oxygen species (ROS) and in mechanisms of multidrug and radiation resistance. Herein, we rationally design two multicomponent self-assembled photodynamic t...