Structural analysis of SARS-CoV-2 genome and predictions of the human interactome

• Main Authors: Vandelli, Andrea, Monti, Michele, Milanetti, Edoardo, Armaos, Alexandros, Rupert, Jakob, Zacco, Elsa, Bechara, Elias, Ponti, Riccardo Delli, Tartaglia, Gian Gaetano
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; ACE2 Protein; Coronavirus Spike Glycoprotein
• Online Access: https://hdl.handle.net/10356/146330
• Institution: Nanyang Technological University

Specific elements of viral genomes regulate interactions within host cells. Here, we calculated the secondary structure content of >2000 coronaviruses and computed >100 000 human protein interactions with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The genomic regions display...