K13-mediated reduced susceptibility to artemisinin in Plasmodium falciparum is overlaid on a trait of enhanced DNA damage repair

• Main Authors: Xiong, Aoli, Prakash, Prem, Gao, Xiaohong, Chew, Marvin, Tay, Ian Jun Jie, Woodrow, Charles J., Engelward, Bevin P., Han, Jongyoon, Preiser, Peter Rainer
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Artemisinin; K13 Protein
• Online Access: https://hdl.handle.net/10356/146590
• Institution: Nanyang Technological University

Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy. While mutations in the kelch propeller domain (K13 mutations) are associated with artemisinin resistance, a range of evidence suggests that...