Discovering putative protein targets of small molecules : a study of the p53 activator Nutlin

• المؤلفون الرئيسيون: Nguyen, Minh N., Sen, Neeladri, Lin, Meiyin, Joseph, Thomas Leonard, Vaz, Candida, Tanavde, Vivek, Way, Luke, Hupp, Ted, Verma, Chandra Shekhar, Madhusudhan, M. S.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Biological sciences; Nutlin; Binding-sites
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/146761
• المؤسسة: Nanyang Technological University

Small molecule drugs bind to a pocket in disease causing target proteins based on complementarity in shape and physicochemical properties. There is a likelihood that other proteins could have binding sites that are structurally similar to the target protein. Binding to these other proteins could alt...