Hydroxyapatite particles induced modulation of collagen expression and secretion in primary human dermal fibroblasts

• Main Authors: Rakshit, Moumita, Gautam, Archana, Toh, Li Zhen, Lee, Ying Shi, Lai, Hui Ying, Wong, Tina T., Ng, Kee Woei
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Nanotechnology; Science::Biological sciences::Molecular biology; Carrier Particles; Collagen Expression
• Online Access: https://hdl.handle.net/10356/146774
• Institution: Nanyang Technological University

Background Hydroxyapatite (HA) [Ca5(PO4)3(OH)] is a naturally occurring calcium phosphate which makes up 60–70% of the dry weight of human bones. Nano-scale HA particles are increasingly being used as carriers for controlled and targeted delivery of bioactive agents like drugs, proteins, and nuclei...