Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression

• المؤلفون الرئيسيون: Teo, Ziqiang, Chan, Jeremy Soon Kiat, Chong, Han Chung, Sng, Ming Keat, Choo, Chee Chong, Phua, Glendon Zhi Ming, Teo, Daniel Jin Rong, Zhu, Pengcheng, Choong, Cleo Swee Neo, Wong, Marcus Thien Chong, Tan, Nguan Soon
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Collagen Expression; Fibroblasts
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89474; http://hdl.handle.net/10220/44977
• المؤسسة: Nanyang Technological University

In adult skin wounds, collagen expression rapidly re-establishes the skin barrier, although the resultant scar is aesthetically and functionally inferior to unwounded tissue. Although TGFβ signaling and fibroblasts are known to be responsible for scar-associated collagen production, there are curren...