Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression

• Main Authors: Teo, Ziqiang, Chan, Jeremy Soon Kiat, Chong, Han Chung, Sng, Ming Keat, Choo, Chee Chong, Phua, Glendon Zhi Ming, Teo, Daniel Jin Rong, Zhu, Pengcheng, Choong, Cleo Swee Neo, Wong, Marcus Thien Chong, Tan, Nguan Soon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Collagen Expression; Fibroblasts
• Online Access: https://hdl.handle.net/10356/89474; http://hdl.handle.net/10220/44977
• Institution: Nanyang Technological University

In adult skin wounds, collagen expression rapidly re-establishes the skin barrier, although the resultant scar is aesthetically and functionally inferior to unwounded tissue. Although TGFβ signaling and fibroblasts are known to be responsible for scar-associated collagen production, there are curren...