Islet transplantation to the anterior chamber of the eye - a future treatment option for insulin-deficient type-2 diabetics? A case report from a nonhuman type-2 diabetic primate

• Main Authors: Tun, Sai Bo Bo, Chua, Minni, Hasan, Riasat, Köhler, Martin, Zheng, Xiaofeng, Ali, Yusuf, Abdulreda, Midhat H., Juntti-Berggren, Lisa, Barathi, Veluchamy A., Berggren, Per-Olof
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Nonhuman Primates; Islet Transplantation
• Online Access: https://hdl.handle.net/10356/146863
• Institution: Nanyang Technological University

Replacement of the insulin-secreting beta cells through transplantation of pancreatic islets to the liver is a promising treatment for type-1 diabetes. However, low oxygen tension, shear stress, and the induction of inflammation lead to significant islet dysfunction and loss. The anterior chamber of...