Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

• Main Authors: Russell, John P., Lim, Xinhong, Santambrogio, Alice, Yianni, Val, Kemkem, Yasmine, Wang, Bruce, Fish, Matthew, Haston, Scott, Grabek, Anaëlle, Hallang, Shirleen, Lodge, Emily J., Patist, Amanda L., Schedl, Andreas, Mollard, Patrice, Nusse, Roel, Andoniadou, Cynthia L.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Stem Cells; SOX2
• Online Access: https://hdl.handle.net/10356/146869
• Institution: Nanyang Technological University

In response to physiological demand, the pituitary gland generates new hormone-secreting cells from committed progenitor cells throughout life. It remains unclear to what extent pituitary stem cells (PSCs), which uniquely express SOX2, contribute to pituitary growth and renewal. Moreover, neither th...