Hierarchical discovery of large-scale and focal copy number alterations in low-coverage cancer genomes

• المؤلفون الرئيسيون: Ahmed Ibrahim Samir Khalil, Khyriem, Costerwell, Chattopadhyay, Anupam, Sanyal, Amartya
• مؤلفون آخرون: School of Computer Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Engineering::Computer science and engineering; Cancer; DNA Copy Number Alteration
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/146948
• المؤسسة: Nanyang Technological University

Background: Detection of DNA copy number alterations (CNAs) is critical to understand genetic diversity, genome evolution and pathological conditions such as cancer. Cancer genomes are plagued with widespread multi-level structural aberrations of chromosomes that pose challenges to discover CNAs of...