Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone

• Main Authors: Raimondo, Domenico, Remoli, Cristina, Astrologo, Letizia, Burla, Romina, La Torre, Mattia, Vernì, Fiammetta, Tagliafico, Enrico, Corsi, Alessandro, Del Giudice, Simona, Persichetti, Agnese, Giannicola, Giuseppe, Robey, Pamela G., Riminucci, Mara, Saggio, Isabella
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Gene Ontologies; Gene Expression
• Online Access: https://hdl.handle.net/10356/147069
• Institution: Nanyang Technological University

Fibrous dysplasia (FD) of bone is a complex disease of the skeleton caused by dominant activating mutations of the GNAS locus encoding for the α subunit of the G protein-coupled receptor complex (Gsα). The mutation involves a substitution of arginine at position 201 by histidine or cysteine (GsαR201...