Capsule-like safe genetic vectors — cell-penetrating core – shell particles selectively release functional small RNA and entrap its encoding DNA

• Main Authors: Yu, Han, Pan, Matthew Houwen, Evalin, Trau, Dieter, Patzel, Volker
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Gene Delivery; Gene Silencing
• Online Access: https://hdl.handle.net/10356/141342
• Institution: Nanyang Technological University

The breakthrough of genetic therapy is set back by the lack of suitable genetic vector systems. We present the development of permeability-tunable, capsule-like, polymeric, micron-sized, core–shell particles for delivery of recombinant nucleic acids into target cells. These particles were demonstrat...