Early endothelial activation precedes glycocalyx degradation and microvascular dysfunction in experimentally induced Plasmodium falciparum and Plasmodium vivax infection

• Main Authors: Woodford, John, Yeo, Tsin Wen, Piera, Kim A., Butler, Kristy, Weinberg, J. Brice, McCarthy, James S., Anstey, Nicholas M., Barber, Bridget E.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Malaria; Falciparum
• Online Access: https://hdl.handle.net/10356/147807
• Institution: Nanyang Technological University

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced Plasmodium falciparum and P. vivax infection. Participants were enrolled in induced blood-stage malaria clinical trials. Plasm...