Glycocalyx breakdown is associated With severe disease and fatal outcome in Plasmodium falciparum malaria

• Main Authors: Yeo, Tsin Wen, Weinberg, J. Brice, Lampah, Daniel A., Kenangalem, Enny, Bush, Peggy, Chen, Youwei, Price, Richard N., Young, Sarah, Zhang, Hao Y., Millington, David, Granger, Donald L., Anstey, Nicholas M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Plasmodium Falciparum; Severe Malaria
• Online Access: https://hdl.handle.net/10356/149019
• Institution: Nanyang Technological University

Background: Interactions between the endothelium and infected erythrocytes play a major role in the pathogenesis of falciparum malaria, with microvascular dysfunction and parasite sequestration associated with worsening outcomes. The glycocalyx is a carbohydrate-rich layer that lines the endotheliu...