Human cells can adaptively evolve to hypomorphic mutations in an essential gene of the nuclear pore complex
Adaptive evolution in response to cellular stress is a critical process implicated in a wide range of core biological and clinical phenomena, including emergence of drug resistance. While it is now widely accepted that single-celled organisms can rapidly adapt to selective pressure, we still lack un...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/147875 |
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| Institution: | Nanyang Technological University |
| Language: | English |