Aβ-mediated nuclear pore complex dysfunction in a mouse model of alzheimer's disease

The nuclear pore complex (NPC) is a vital component of the nuclear envelope that regulates multiple processes including nucleocytoplasmic shuttling, chromosome organisation, and transcriptional regulation. While gradual loss of NPCs occurs in neurons during ageing, further dysregulation has been rep...

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Bibliographic Details
Main Author: Vibhavari, Bansal
Other Authors: Chng Toh Hean
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/169886
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Institution: Nanyang Technological University
Language: English