Human cells can adaptively evolve to hypomorphic mutations in an essential gene of the nuclear pore complex

• المؤلف الرئيسي: Targa, Altea
• مؤلفون آخرون: Koh Cheng Gee
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2021
• الموضوعات: Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/147875

Adaptive evolution in response to cellular stress is a critical process implicated in a wide range of core biological and clinical phenomena, including emergence of drug resistance. While it is now widely accepted that single-celled organisms can rapidly adapt to selective pressure, we still lack un...