Carbene-catalyzed N,N-nucleophilic activation of thioureas for access to pyrimidinthione derivatives

Carbene-catalyzed N,N-nucleophilic activation of thioureas for access to pyrimidinthione derivatives

An N-heterocyclic carbene-catalyzed [3+3] cycloaddition reaction of acylthioureas with ynals is reported. Both N atoms in the thiourea substrate are activated as nucleophiles and incorporated inside the ring system of the product. Pyrimidinthione derivatives bearing various substituents and substitu...

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Bibliographic Details
Main Authors: Cao, Liya, Li, Tingting, Chi, Robin Yonggui, Jin, Zhichao
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Chemistry
Nucleophilic Addition
Organocatalysis
Online Access:https://hdl.handle.net/10356/148229
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Institution: Nanyang Technological University
Language: English
Description
Summary:An N-heterocyclic carbene-catalyzed [3+3] cycloaddition reaction of acylthioureas with ynals is reported. Both N atoms in the thiourea substrate are activated as nucleophiles and incorporated inside the ring system of the product. Pyrimidinthione derivatives bearing various substituents and substitution patterns are afforded as the products in moderate to good yields.

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