Characterization of ALS-associated proteins in Saccharomyces cerevisiae

Various mutations in the low complexity domain of RNA-binding proteins such as TDP-43, FUS and hnRNPA1 have been identified from familial ALS (Amyotrophic Lateral Sclerosis) patients. Aggregation of these RNA-binding proteins, particularly TDP-43, is a hallmark of ALS. It is notable that these ALS-a...

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Bibliographic Details
Main Author: Ng, Qing Hao
Other Authors: Choe Young Jun
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2021
Subjects:
Online Access:https://hdl.handle.net/10356/148412
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Institution: Nanyang Technological University
Language: English