Characterization of ALS-associated proteins in Saccharomyces cerevisiae
Various mutations in the low complexity domain of RNA-binding proteins such as TDP-43, FUS and hnRNPA1 have been identified from familial ALS (Amyotrophic Lateral Sclerosis) patients. Aggregation of these RNA-binding proteins, particularly TDP-43, is a hallmark of ALS. It is notable that these ALS-a...
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| Format: | Final Year Project |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/148412 |
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| Institution: | Nanyang Technological University |
| Language: | English |