Characterization of ALS-associated proteins in Saccharomyces cerevisiae

• Main Author: Ng, Qing Hao
• Other Authors: Choe Young Jun
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/148412
• Institution: Nanyang Technological University

Various mutations in the low complexity domain of RNA-binding proteins such as TDP-43, FUS and hnRNPA1 have been identified from familial ALS (Amyotrophic Lateral Sclerosis) patients. Aggregation of these RNA-binding proteins, particularly TDP-43, is a hallmark of ALS. It is notable that these ALS-a...