Characterization of ALS-associated proteins in Saccharomyces cerevisiae

• 主要作者: Ng, Qing Hao
• 其他作者: Choe Young Jun
• 格式: Final Year Project
• 語言: English
• 出版: Nanyang Technological University 2021
• 主題: Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/148412

Various mutations in the low complexity domain of RNA-binding proteins such as TDP-43, FUS and hnRNPA1 have been identified from familial ALS (Amyotrophic Lateral Sclerosis) patients. Aggregation of these RNA-binding proteins, particularly TDP-43, is a hallmark of ALS. It is notable that these ALS-a...