Linear and cyclic short cationic peptides as antibiotic potentiators against drug resistant Gram-negative bacteria

• Main Author: Tan, Ee Heng
• Other Authors: Surajit Bhattacharyya
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/148439
• Institution: Nanyang Technological University

Treatment of gram-negative bacteria infections presents a challenge predominantly due to asymmetrical distribution of Lipopolysaccharide(LPS) in the outer leaflet of outer membrane, posing a permeability barrier to various anti-microbial agents. Consequently, anti-microbial peptides that perturb the...