High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons

• المؤلفون الرئيسيون: Cavallo, Francesca, Troglio, Flavia, Fagà, Giovanni, Fancelli, Daniele, Shyti, Reinald, Trattaro, Sebastiano, Zanella, Matteo, D'Agostino, Giuseppe, Hughes, James M., Cera, Maria Rosaria, Pasi, Maurizio, Gabriele, Michele, Lazzarin, Maddalena, Mihailovich, Marija, Kooy, Frank, Rosa, Alessandro, Mercurio, Ciro, Varasi, Mario, Testa, Giuseppe
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; Autism Spectrum Disorder; 7q11.23 Duplication Syndrome
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/148599
• المؤسسة: Nanyang Technological University

Background: Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available. Duplication at 7q11.23 (7Dup), encompassing 26-28 genes, is one of the best characteriz...