High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons

• Main Authors: Cavallo, Francesca, Troglio, Flavia, Fagà, Giovanni, Fancelli, Daniele, Shyti, Reinald, Trattaro, Sebastiano, Zanella, Matteo, D'Agostino, Giuseppe, Hughes, James M., Cera, Maria Rosaria, Pasi, Maurizio, Gabriele, Michele, Lazzarin, Maddalena, Mihailovich, Marija, Kooy, Frank, Rosa, Alessandro, Mercurio, Ciro, Varasi, Mario, Testa, Giuseppe
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Autism Spectrum Disorder; 7q11.23 Duplication Syndrome
• Online Access: https://hdl.handle.net/10356/148599
• Institution: Nanyang Technological University

Background: Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available. Duplication at 7q11.23 (7Dup), encompassing 26-28 genes, is one of the best characteriz...